Question about renin, angiotensin, aldosterone student. The physiological importance of the raas is the compensation of hypovolemia, hyponatremia and hypotension. Blockers of the renin angiotensin aldosterone system raas, that is, renin inhibitors, angiotensin angconverting enzyme ace inhibitors, ang ii type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the treatment of hypertension. Regulation of renin release and impact of loop diuretic therapy. This site was designed with the wix website builder. The reninangiotensin aldosterone system raas plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure. The biochemistry of the reninangiotensin system and its.
Dr najeeb wedding photos, dr najeeb family pictures, dr najeeb marriage pics. This is renin angiotensin aldosterone system by dr. Renin angiotensin aldosterone system flashcards quizlet. The reninangiotensinaldosterone system raas is a well known regulator of blood pressure bp and determinant of target organ damage. Reninangiotensinaldosterone system in renal longdom. The renin angiotensin system has an important role in maintaining elevated blood pressure levels in certain forms of experimental and human hypertension. The reninangiotensinaldosterone system raas generates the peptide hormone angiotensin ii and subsequently the mineralocorticoid aldosterone, which both exert considerable impact on blood pressure blood pressure control and fluid homeostasis, and have prime etiologic and therapeutic significance for cardiovascular diseases. Angiotensin ii causes vasoconstriction increasing hydrostatic pressure in capillaries and eventually edema is produced. In humans, angrelated genes are activated at stage 11 of the developing embryo, 246 which corresponds to 23 to 24 days of gestation. The renin angiotensin system ras, or renin angiotensin aldosterone system raas, is a hormone system that regulates blood pressure and fluid and electrolyte balance, as well as systemic vascular resistance. The reninangiotensin system ras has emerged as a key target for the management of hypertension. Renin angiotensin system ras or renin angiotensin aldosterone system raas does a lot of functions. Pathophysiological role and pharmacologic inhibition steven a.
If you continue browsing the site, you agree to the use of cookies on this website. Najeeb lectures medical lectures videos syed arslan ali shah 08112017 renin angiotensin aldosterone system 17 dr. Start studying renin angiotensin aldosterone system. Overactivity of the renin angiotensin aldosterone system is what i had read to be one of the main causes of essential.
Najeeb lectures on vimeo, the home for high quality videos and the people who love them. Reninangiotensinaldosterone system definition of renin. Najeeb lectures are the worlds most popular lectures on basic medical sciences watched by. The reninangiotensin system ras, or reninangiotensinaldosterone system raas, is a hormone system that regulates blood pressure and fluid and. The 1960s was the decade dominated by the vietnam war, civil rights protests, cuban missile crisis, antiwar protests and saw the assassinations of us president john f. Angiotensin ii ang ii, the major effector of the renin angiotensin aldosterone system raas, stimulates the production of reactive oxygen species ros which are critically involved in ang iiinduced effects. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha2 globulin produced by the liver, forming angiotensin i. Najeeb medical lectures videos if you found this video helpful then please like subscribe and share. His first youtube address was transferred on june 14, 2009, and was titled renin angiotensin aldosterone system 17. As the name implies, there are three important components to this system. The raas plays a central role in blood pressure regulation and consists of a cascade of functional proteins renin, angiotensinogen, angiotensin i and ii fig. The role of reninangiotensinaldosterone system in the progression of chronic kidney disease the renin angiotensin aldosterone system raas is a well known regulator of blood pressure bp and determinant of targetorgan damage. In the presence of albuminuria, it is suggested that ras blockade with angiotensin converting enzyme inhibitors acei or angiotensin receptor blockers arbs should be the first line of antihypertensive treatment.
Enter the url of the youtube video to download subtitles in many different formats and languages. Watch more videos at renin angiotensin aldosterone system. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Download subtitles and closed captions cc from youtube. Renin, an enzyme produced by the juxtaglomerular cells of the kidney, acts on a protein substrate found in the alpha 2globulin fraction of the plasma to produce a decapeptide, angiotensin i. Browse 44 sets of renin physiology flashcards advanced. Renin angiotensin aldosterone system ecg interpretation cardiac cycle spinothalamic tract urine concentration and dilution complement system. This video shows lecture on renin angiotensin aldosterone system dr. The local cardiac reninangiotensin aldosterone system, second edition updates new findings on the local renin angiotensin systems ras with a focus on the local raass of the cardiovascular system and kidney edward d. Aldosterone brings about sodium retention, water retention. So, search there dr najeeb neuroanatomy lectures torrents. Vdyoutube renin angiotensin aldosterone system raas. This video shows lecture on renin angiotensin aldosterone system. Nephrotic and nephritic syndrome renal pathology by dr.
Raas introduction coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function that governs fluid and electrolyte balance and arterial pressure. Renin angiotensin aldosterone system 37 couretsy dr najeeb. Renin angiotensin aldosterone system 37 couretsy dr najeeb posted by dr saghir ahmad at. Dr najeeb wedding photos, family pictures, marriage pics.
Renin hydrolyzes a plasma globulin to release angiotensin i, which is rapidly hydrolyzed to angiotensin ii, which in turn stimulates aldosterone secretion. The majority of ang ii is derived from the precursor angiotensin i ang i, which originates from angiotensinogen, produced by the liver. When blood pressure drops down below the norm either because of dehydration or a hemorrhage, the kidneys release an enzyme called renin. The renin angiotensin aldosterone system raas is a hormone system that regulates blood pressure and fluid balance. Noteworthy, accumulating evidence indicates that ros also regulate the activation of raas, contributing to the finetuning of this system under physiological conditions or to the. Journal of reninangiotensinaldosterone system published online 6 february 2014 mayur garg, louise m burrell, elena velkoska, karen griggs, peter w angus, peter r gibson and john s lubel.
The reninangiotensin aldosterone system raas is a hormonal cascade that functions in the homeostatic control of arterial pressure, tissue perfusion, and extracellular volume. The reninangiotensinaldosterone system during cardiac surgery with morphinenitrous. Function of renin angiotensin aldosterone system raas. Due to accumulation of fluid in interstitial tissue, blood volume in circulatory system decreases leading to hypoperfusion of kidneys which activate rennin angiotensin aldosterone axis. Dr najeeb lectures archives page 30 of 30 free pdf books.
Renin angiotensin aldosterone system angiotensin ii ang ii, a potent vasoconstrictor, stimulates the formation and secretion of aldosterone from the adrenal gland, and has pleiotropic effects on cellular growth. Regulation of the reninangiotensinaldosterone system by. Function of nephron in kidney regulation of gfr renal system physiology. Renin angiotensin system ras or renin angiotensin aldosterone system raas does a lot of functions most importantly blood pressure regulation. The role of reninangiotensinaldosterone system in the. Human body diagrams how to derive an image derive directly from raster image with organs. When renal blood flow is reduced, juxtaglomerular cells in the kidneys convert the precursor prorenin already present in the blood into renin and secrete it directly into circulation. I had never heard the enac channel being directly implicated in essential hypertension, but i guess it would make sense since it is activated by aldosterone, and aldosterone secretion is stimulated by the renin angii system. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. This pathway is a biochemical system which originates in the kidneys. The reninangiotensin system in mammals is represented in nonmammals by the juxtaglomerular cells that secrete renin associated with the renin is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys the renal capillary networks that are the filtration units of.
793 56 720 1256 260 6 639 233 527 151 263 1164 529 183 747 1422 1309 1409 1454 1105 665 393 1263 211 716 252 643 97 32 420 785 913 540 1257 428 233 1428